Dr. Elpida Fragouli is the Laboratory Director of IVI-RMA’s Oxford Basic Research Centre, which is based in Oxford, UK, as well as holding a research position at the Universit y of Oxford.
Education and training
Dr. Fragouli obtained her Bachelor of Science (Hons) in Molecular Biology from the University of Surrey, and a Masters of Science in Biochemistry (Genetic Manipulation and Molecular Biology) from the University of Sussex. She went on to obtain a second Masters of Science in Prenatal Genetics and Fetal Medicine from University College London, followed by a PhD in Human Genetics, also from University College London (UCL). She previously worked at the UCL Centre for Preimplantation Genetic Diagnosis (PGD) and Yale University Medical School (New Haven, CT, USA) and for 10 years was the Laboratory Director of Reprogenetics UK in Oxford.
Dr. Fragouli’s main research interests focus on the genesis of chromosome abnormalities in human gametes, design and application of novel methodologies aimed to improve embryological parameters, outcomes after in vitro fertilization, and identification of patient characteristic traits that could affect fertility and infertility. Additionally, her research into finding biomarkers of embryo competence identified several target genes with differential expression in cumulus cells surrounding aneuploid oocytes. Moreover, Dr. Fragouli’s research group were the first to identify the possible role of mitochondrial DNA as a predictor of embryo implantation potential. On a clinical level, her work played a key role during the development, validation, and clinical application of comparative genomic hybridization (CGH), a method which formed the basis of preimplantation genetic testing of aneuploidy and the PGD of structural chromosome rearrangements via the use of comprehensive molecular cytogenetic methodologies.
Dr. Fragouli has published more than 150 peer-reviewed papers, abstracts, and book chapters, and she is currently a member of the editorial boards of Human Reproduction, Fertility and Sterility, and Reproductive BioMedicine Online and a reviewer for a number of journals, including those mentioned above.
Honors and Recognitions
Dr. Fragouli has been the recipient of multiple awards for her work, including the New England Fertility Society-PCRS Exchange Prize for best submitted abstract (2007) awarded for her work on CGH analysis of trophectoderm samples biopsied from blastocyst stage embryos, the ESHRE Basic Science Prize (2011) for her work on the transcriptome of cumulus cells, and the ASRM SART (2015) Prize for her work on the assessment of the mitochondrial genome of human embryos. She is also frequently invited to national and international conferences to give educational lectures on subjects related to reproductive biology and the genetics of early human development.